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Post-doc position - Institut Curie (Paris)

Project. During inflammation, monocytes are rapidly recruited and differentiate in situ into monocyte-derived macrophages (mo-Mac) and monocyte-derived dendritic cells (mo-DC). In chronic inflammatory diseases, mo-DC fuel the inflammation and are major contributors to tissue damage, while in cancer mo-Mac play a key role in suppressing anti-tumoral immune responses. How monocytes differentiate into mo-DC or mo-Mac is still poorly characterized. A better understanding of the molecular ontogeny of monocyte-derived cells would provide novel targets for the therapeutic manipulation of monocyte differentiation. We have recently shown that the Aryl Hydrocarbon Receptor is a molecular switch for directing monocyte differentiation towards mo-DC versus mo-Mac (Goudot et al, 2017). The successful candidate will employ molecular biology, cellular immunology and mouse models to unravel the transcriptional networks involved in the regulation of mo-Mac versus mo-DC differentiation by the Aryl Hydrocarbon Receptor.

Candidate profile. We are looking for a qualified, intellectually curious and highly motivated candidate holding a Ph.D. in biology, preferably in immunology, molecular biology or genomics. Familiarity with the following techniques will be an advantage but is not mandatory: flow cytometry, gene regulation/chromatin biology, lentiviral infections and bio-informatics. Strong organizational and communication skills and independence are essential. Written and spoken English is mandatory. Salary will be dependent on diploma and experience.

Opened from September 2017 until filled.
Please send CV, motivation letter and contact details of at least two persons able to provide references to elodie.segura (at) curie.fr

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