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Research Associate in Mucosal Immunology
University of Manchester
Closing Date : 04/01/2018
Division : Infection, Immunity & Respiratory Medicine
Salary : £31,604 to £38,833 per annum
Job Reference : BM&H-11090

This is an opportunity for a highly motivated mucosal immunologist to
work on a full-time BBSRC funded project, investigating mechanisms of
immune surveillance at the oral barrier. You will be a Research
Associate in the laboratory of Dr. Joanne Konkel in the University of
Manchester’s Collaborative Centre for Inflammation Research (MCCIR)
and Faculty of Biology, Medicine and Health.
We are looking for an enthusiastic individual to plan and direct a
research program exploring the immune-surveillance network
policing the mucosal barriers of the mouth, defining the
mechanisms by which this network is conditioned and educated
by the local tissue environment to safeguard oral barrier immune
homeostasis.

You will be expected to develop and drive your own research project,
pursue your research objectives in a rigorous and efficient manner and
present your findings via peer-reviewed publications and oral
presentations. Candidates must hold a PhD (or expect to obtain one
shortly) in Immunology, with extensive theoretical and practical
knowledge of mucosal immunology. Expertise in flow cytometry, in vivo
models, and primary immune cell isolation are essential. Candidates
should have a good publication record and hold a Home Office License.

Further Details:
https://www.jobs.manchester.ac.uk/displayjob.aspx?jobid=14434
Enquiries about the vacancy, shortlisting and interviews:
Name: Joanne E. Konkel
Email: joanne.konkel@manchester.ac.uk
This vacancy will close for applications at midnight on the closing date. As an equal
opportunities employer we welcome applicants from all sections of the community regardless
of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are
made on merit.

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Postdoctoral position available in the “Nods-like receptors in infection and immunity” Group at the Institut Pasteur de Lille

A funded two-year postdoctoral position is available in the “Nods-like receptors in infection and immunity of Lille” Unit headed by Mathias Chamaillard for studying how oscillatory behavior of the gut microbiota influence the specification fate of monocyte toward monocyte-derived macrophages or monocyte-derived dendritic cells by dictating the tolerogenic versus immunogenic intestinal microenvironment over the course of a day. The Chamaillard's laboratory at the Institut Pasteur de Lille is interested in defining how deregulation of several Nods-like receptors break down in colitis-associated colorectal cancer. Using a variety of techniques and complex genetic models, we have contributed to the field of mucosal immunology by identifying novel dendritic cell subsets and several pathways that underlie inflammation-driven carcinogenesis (Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9601-6, J Clin Invest. 2013 Feb;123(2):700-11 and Mucosal Immunol. 2017 Nov 15. doi: 10.1038/mi.2017.87).

Project Outline: The International Agency for Research on Cancer classified shift work with chronodisruption as an exposure circumstance that poses a carcinogenic risk. The circadian clock is an endogenous time-tracking system that allows most living organisms to anticipate and adapt to several environmental changes. In this context, we seek to obtain a mechanistic understanding how circadian rhythm influence the continuous replenishment of the pool of intestinal macrophages by influx of monocytes from the bloodstream. Thanks to excellent facilities at the Institut Pasteur de Lille and to strong collaborations with the Institute Pasteur of Paris and the inflammation research center from the VIB in Ghent, state-of-the-art technologies are available including those combining imaging and flow cytometry. The scientific outputs of our multidisciplinary approach has a direct clinical perspective that will have a broad impact on the development of chronomodulated drugs as exemplified by the strong of interest of stakeholders and biotech companies on the gut microbiota in oncology. Upon completion of the project, we will look for collaboration with industrial partners involved in microbiota-derived molecule development and next generation probiotics development in order to favor public-private partnership either locally or internationally for transfering our results from bench to bedside through clinical trial.

Candidate requirements: The applicants of any nationality must hold a PhD and/or a MD degree and should be highly motivated and ambitious. The applicants should have a strong background in bone marrow chimera experiments, cell cytometry and cellular imaging with a strong interest on oncology and mucosal immunology. Technical expertise in flow cytometry will be of advantage. Fluent knowledge of English and excellent communication skills are expected. Interested candidates are encouraged to submit a motivation letter describing their background, a CV and two references letters to mathias.chamaillard@inserm.fr.

Expected employment starting date: 2018-01-01.





POST-DOCTORAL POSITION AT INSTITUT CURIE (PARIS)

Context and environment: A post-doc position is available with Elodie Segura in the
“Immunity and Cancer” department of Institut Curie. The group studies the biology of human
antigen-presenting cells in health and pathology, by combining analysis of human cells
directly isolated from tissues, in vitro models using human cells, and in vivo models in mice.

During inflammation, monocytes are rapidly recruited and differentiate in situ into monocytederived
macrophages (mo-Mac) and monocyte-derived dendritic cells (mo-DC). In chronic
inflammatory diseases, mo-DC fuel the inflammation and are major contributors to tissue
damage, while in cancer mo-Mac play a key role in suppressing anti-tumoral immune
responses. How monocytes differentiate into mo-DC or mo-Mac is still poorly characterized.
A better understanding of the molecular ontogeny of monocyte-derived cells would provide
novel targets for the therapeutic manipulation of monocyte differentiation. We have recently
shown that the Aryl Hydrocarbon Receptor is a molecular switch for directing monocyte
differentiation towards mo-DC versus mo-Mac (Goudot et al, 2017). The successful
candidate will employ molecular biology, cellular immunology and mouse models to unravel
the transcriptional networks involved in the regulation of mo-Mac versus mo-DC
differentiation by the Aryl Hydrocarbon Receptor.

Institut Curie is one of the largest European institutions for cancer research with a strong
interdisciplinary tradition and state-of-the-art core facilities. It is located in the center of Paris
(France), in a rich cultural and scientific environment. The Immunology department, headed
by Sebastian Amigorena, includes 10 independent research groups in fundamental and
translational immunology, working in a very collaborative and international environment.

Candidate profile: We are looking for a qualified, intellectually curious and highly motivated
candidate holding a Ph.D. in biology, preferably in immunology, molecular biology or
genomics. Familiarity with the following techniques will be an advantage but is not
mandatory: flow cytometry, gene regulation/chromatin biology, lentiviral infections and bioinformatics.
Strong organizational and communication skills and independence are essential.
Written and spoken English is mandatory. Salary will be dependent on diploma and
experience.

Application : Opened from September 2017 until filled.
Please send CV, motivation letter and contact details of at least two persons able to provide
references to elodie.segura (at) curie.fr

http://esegura-lab.org
http://u932.curie.fr/

Goudot C, Coillard A, Villani AC, Gueguen P, Cros A, Sarkizova S, Tang-Huau TL, Bohec M,
Baulande S, Hacohen N, Amigorena S, Segura E (2017). Aryl hydrocarbon receptor controls
monocyte differentiation into dendritic cells versus macrophages., Immunity. 47: 1-15.